Which HIPAA rule mandates safeguarding electronic personal health information?

The Security Rule specifically mandates the safeguarding of electronic personal health information (ePHI). It establishes national standards for protecting the confidentiality, integrity, and availability of ePHI. This rule requires covered entities and their business associates to implement various administrative, physical, and technical safeguards to ensure that electronic health information is protected from unauthorized access and breaches.

While the Privacy Rule addresses the use and disclosure of individuals' health information, it does not specifically focus on the electronic aspects like the Security Rule does. The Ethics Rule and the Scope of Practice Rule, on the other hand, pertain more to the professional conduct and responsibilities of healthcare providers and do not directly address the safeguarding of electronic health information.

Thus, the Security Rule is the correct answer as it directly pertains to the protection measures for electronic personal health information in compliance with HIPAA regulations.